Emerging Treatments: Review of Research Studies for Tinnitus

Treatment

Indication

Development Stage

Status

Links

Bimodal stimulation (University of Michigan)

Chronic tinnitus

Small-scale study

Clinical trial ID:

NCT02974543

Completed

A larger scale study is planned.

Oxytocin

Chronic tinnitus

Pilot study

Completed

Further studies warranted

Electrical stimulation of the ear

Chronic tinnitus

Several studies (small, large, blinded, enhanced treatment protocols, advanced diagnostics).

Completed

Cognitive training

Chronic tinnitus

Open-label, randomized

Completed

Meditation

Chronic tinnitus

Large-scale randomized trials

Completed

Vagus nerve stimulation (implant)

Chronic tinnitus

Small-scale randomized blinded study (with subsequent cross-over)

Clinical trial ID: NCT01962558

Completed

ACRN (acoustic coordinated reset neuromodulation)

Chronic tinnitus

Small-scale and medium-scale clinical studies (blinded and open-label, respectively)

Completed

Residual inhibition

Sub-acute/chronic tinnitus

Small-scale clinical study (open-label)

Completed

Variants of rTMS

Chronic tinnitus

Small-scale studies (randomized, open-label)

Completed

Further studies warranted

Radiofrequency lesioning

Tinnitus

Large-scale retrospective study

Completed

Further studies warranted

AM-101 (Auris Medical AG)

Acute tinnitus

Phase-III extended clinical trial

Clinical trial IDs:

NCT02040194

NCT01803646

NCT01270282

NCT00860808

NCT02040207

NCT01934010

Completed: dual phase-III trials failed to demonstrate efficacy (in both subgroups) – pending final confirmation of status from Auris Medical

OTO-313 (Otonomy Inc)

Tinnitus

Phase-I (OTO-311)

Completed

Phase-I/II trial in tinnitus patients expected to begin in first half of 2019

AM-102 (Auris Medical AG)

Acute tinnitus

Preclinical

Lead compound selection expected in 2nd quarter 2018

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